Influence of vitamin E on polyamine metabolism in ozone-exposed rat lungs

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Arch. Biochem. Biophys.; (United States)

DOI:https://doi.org/10.1016/0003-9861(87)90407-3· OSTI ID:6465219

Elsayed, N M

The influence of vitamin E (E) on lung polyamine metabolism of rats exposed to ozone (O/sub 3/) was examined. Rats fed diets either E-deficient or supplemented with 1000 IU E/kg were exposed to 0.5 +/- 0.05 ppm O/sub 3/ or filtered room air continuously for 5 days. They were then sacrificed and their lungs were analyzed for biochemical changes. Lung E content was strongly associated with the dietary level, and increased (36%, P less than 0.05) after O/sub 3/ exposure only in E-supplemented rats. Lung polyamine metabolism was not affected in the air-control rats by E level, but increased after O/sub 3/ exposure in both dietary groups. The activities of ornithine decarboxylase and S-adenosylmethionine decarboxylase were elevated above air controls. However, the increases were significant only for E-deficient rats when compared to E-supplemented rats. After O/sub 3/ exposure, putrescine increased significantly in both dietary groups; spermidine increased but was significantly higher only in the E-deficient group; and spermine remained unchanged in both dietary groups. Elevated E content of supplemented rat lungs after O/sub 3/ exposure may represent its mobilization under oxidant stress. Increased polyamine metabolism of E-deficient rats suggests either a greater sensitivity to injury by O/sub 3/ or a possible antioxidant function for polyamines compensating for E deficiency.

• Research Organization: Univ. of California, Los Angeles
• OSTI ID: 6465219
• Journal Information: Arch. Biochem. Biophys.; (United States), Journal Name: Arch. Biochem. Biophys.; (United States) Vol. 2; ISSN ABBIA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBON-CARBON LYASES
CARBOXY-LYASES
DECARBOXYLASES
ENZYMES
LUNGS
LYASES
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANS
OZONE
PUTRESCINE
RATS
RESPIRATORY SYSTEM
RODENTS
SPERMIDINE
SPERMINE
TOXICITY
VERTEBRATES
VITAMIN E
VITAMINS