Biological monitoring using cellular macromolecules
- Oak Ridge National Lab., TN (USA)
DNA damage has been proposed as a useful biological marker for assessing the genotoxic properties of environmental pollutants. Many of these pollutants are chemical carcinogens and mutagens with the capacity to cause various types of DNA damage. Genotoxic chemicals may form stable adducts with DNA, adducts which result in the formation of alkali-labile apurinic sites, and unstable adducts which cause strand breaks. Additional damage may occur through the inhibition of normal DNA repair. Each type of damage may contribute toward the eventual transformation of the cell. Analytical techniques that measure DNA damage have been developed at the Oak Ridge National Laboratory and have been used to assess the status of DNA in organisms exposed to chemical carcinogens under controlled laboratory conditions, and to fish and marine mammals from polluted and non-polluted environments. Preliminary data indicate the feasibility of monitoring DNA damage in an organism as a biological marker of environmental genotoxicity.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 7018216
- Report Number(s):
- CONF-8909236--
- Journal Information:
- Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA), Journal Name: Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA) Vol. 28:2; ISSN 0099-7293; ISSN ACWCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
540120 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (1990-)
540220 -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (1990-)
540320 -- Environment
Aquatic-- Chemicals Monitoring & Transport-- (1990-)
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
ANIMALS
AQUATIC ORGANISMS
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOSYNTHESIS
CARCINOGENS
DNA
DNA ADDUCTS
DNA REPAIR
FISHES
GENETIC EFFECTS
MUTAGENS
NATIONAL ORGANIZATIONS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORNL
POLLUTION
RECOVERY
REPAIR
STRAND BREAKS
SYNTHESIS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
VERTEBRATES
XENOBIOTICS