Biologic markers in risk assessment for environmental carcinogens

Journal Article · Mon Dec 31 23:00:00 EST 1990 · Environmental Health Perspectives; (United States)

DOI:https://doi.org/10.2307/3430875· OSTI ID:5074036

Perera, F; Mayer, J; Santella, R M; Brenner, D; Jeffrey, A; Latriano, L; Smith, S; Warburton, D; Young, T L; Tsai, W Y; Brandt-Rauf, P ^[1]; Hemminki, K ^[2]

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1. Columbia Univ. School of Public Health, New York, NY (United States)
2. Finnish School of Occupational Health, Helsinki (Finland)

The potential of biologic markers to provide more timely and precise risk assessments for environmental carcinogens is viewed against the current state-of-the-art in biological monitoring/molecular epidemiology. Biologic markers such as carcinogen-DNA adducts and oncogene activation are currently considered valid qualitative indicators of potential risk, but for most chemical exposures research is needed to establish their validity as quantitative predictors of cancer risk. Biologic markers have, however, already provided valuable insights into the magnitude of interindividual variation in response to carcinogenic exposures, with major implications for risk assessment.

• OSTI ID: 5074036
• Journal Information: Environmental Health Perspectives; (United States), Journal Name: Environmental Health Perspectives; (United States) Vol. 90; ISSN 0091-6765; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560300* -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
BIOASSAY
BIOLOGICAL MARKERS
BODY
CARCINOGENESIS
CARCINOGENS
CHEMICAL ACTIVATION
DNA ADDUCTS
ENVIRONMENTAL EXPOSURE
EPIDEMIOLOGY
GENES
LUNGS
ONCOGENES
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATIENTS
PROTEINS
RESPIRATORY SYSTEM