Molecular epidemiology and cancer prevention

Journal Article · Sun Dec 31 23:00:00 EST 1989 · Cancer Detection and Prevention; (USA)

OSTI ID:6244871

Perera, F P; Jeffrey, A M; Brandt-Rauf, P W; Brenner, D; Mayer, J L; Smith, S J; Latriano, L; Hemminki, K; Santella, R M ^[1]

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1. Columbia Univ. School of Public Health, New York, NY (USA)

A review of recent studies of biologic markers in populations with model exposures to carcinogens (cigarette smoke and polycyclic aromatic hydrocarbons) illustrates their potential role in cancer prevention. Data on macromolecular adducts and oncogene activation from cross-sectional, serial sampling and case-control studies demonstrate the usefulness of biologic markers in signalling a potential carcinogenic risk and in estimating the magnitude of interindividual variation within exposed groups. Recommendations for future research include nested case-control studies to establish the relationship between markers of biologic dose and effect (e.g., adducts, gene mutation, oncogene activation) and cancer risk. 31 references.

• OSTI ID: 6244871
• Journal Information: Cancer Detection and Prevention; (USA), Journal Name: Cancer Detection and Prevention; (USA) Vol. 14:6; ISSN 0361-090X; ISSN CDPRD
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADDUCTS
AEROSOLS
ANIMALS
AROMATICS
BIOLOGICAL MARKERS
CARCINOGENESIS
COLLOIDS
DISEASES
DISPERSIONS
DNA ADDUCTS
DOCUMENT TYPES
EPIDEMIOLOGY
GENES
HYDROCARBONS
MAMMALS
MAN
NEOPLASMS
ONCOGENES
ORGANIC COMPOUNDS
PATHOGENESIS
POLYCYCLIC AROMATIC HYDROCARBONS
PRIMATES
RECOMMENDATIONS
RESIDUES
REVIEWS
RISK ASSESSMENT
SMOKES
SOLS
TOBACCO SMOKES
VERTEBRATES