Tubular transport and metabolism of cimetidine in chicken kidneys

Journal Article · Wed Feb 01 04:00:00 EST 1984 · J. Pharmacol. Exp. Ther.; (United States)

OSTI ID:7013816

Rennick, B; Ziemniak, J; Smith, I; Taylor, M; Acara, M

Renal tubular transport and renal metabolism of (/sup 14/C)cimetidine (CIM) were investigated by unilateral infusion into the renal portal circulation in chickens (Sperber technique). (/sup 14/C)CIM was actively transported at a rate 88% that of simultaneously infused p-aminohippuric acid, and its transport was saturable. The following organic cations competitively inhibited the tubular transport of (/sup 14/C)CIM with decreasing potency: CIM, ranitidine, thiamine, procainamide, guanidine and choline. CIM inhibited the transport of (/sup 14/C)thiamine, (/sup 14/C)amiloride and (/sup 14/C)tetraethylammonium. During CIM infusion, two renal metabolites, CIM sulfoxide and hydroxymethylcimetidine, were found in urine. When CIM sulfoxide was infused, its transport efficiency was 32% and not saturable. CIM sulfoxide did ot inhibit the simultaneous renal tubular transport of p-aminohippuric acid or tetraethylammonium. CIM is transported by the organic cation transport system and the kidney metabolizes CIM. Transport of CIM and other cationic drugs could produce a drug interaction to alter drug excretion.

• Research Organization: State Univ. of New York, Buffalo
• OSTI ID: 7013816
• Journal Information: J. Pharmacol. Exp. Ther.; (United States), Journal Name: J. Pharmacol. Exp. Ther.; (United States) Vol. 228:2; ISSN JPETA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
BODY
CARBON 14 COMPOUNDS
CHICKENS
CLEARANCE
DRUGS
EXCRETION
FOWL
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
MEMBRANE TRANSPORT
METABOLISM
ORGANS
PERFUSED ORGANS
RENAL CLEARANCE
TRACER TECHNIQUES
VERTEBRATES