Differential inhibition of organic cations by the renal tubule of the chicken: relationship to Tm

Conference · Sat Mar 01 04:00:00 EST 1986 · Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)

OSTI ID:5496661

Springate, J; Hasan, M; Rennick, B; Acara, M

The ability of organic cations to differentially inhibit the renal excretion of two prototypical organic cations, tetraethylammonium (TEA) and N/sup 1/-methylnicotinamide (NMN), was investigated using the Sperber technique in chickens. /sup 3/H-TEA and /sup 14/C-NMN were infused simultaneously into the renal portal circulation and their transport efficiencies (TE) determined to be 106 +/- 11% and 81 +/- 13% respectively. Quinine, unlabelled NMN or TEA, added in increasing amounts, produced differential inhibition of TEA, NMN, or cimetidine (infused in separate experiments). Data using other competing organic cations (guinidine, ranitidine, triethylcholine) indicated that TEA was never more susceptible to inhibition than NMN. These results suggest that the magnitude of T/sub m/ is directly related to susceptibility to inhibition and indirectly to inhibitory potency.

• Research Organization: SUNY, Buffalo, NY
• OSTI ID: 5496661
• Report Number(s): CONF-8604222-
• Conference Information: Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMIDES
AMMONIUM COMPOUNDS
ANIMALS
AZINES
BIRDS
BODY
CARBON 14 COMPOUNDS
CATIONS
CHARGED PARTICLES
CHICKENS
CLEARANCE
EXCRETION
FOWL
HETEROCYCLIC COMPOUNDS
INHIBITION
IONS
ISOTOPE APPLICATIONS
KIDNEYS
LABELLED COMPOUNDS
NICOTINAMIDE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
TUBULES
VERTEBRATES
VITAMIN B GROUP
VITAMINS