Murine survival of lethal irradiation with the use of human umbilical cord blood

Journal Article · Wed Jan 01 04:00:00 EST 1992 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90013-F· OSTI ID:7013508

Ende, N; Ponzio, N M; Athwal, R S; Giuliani, D C ^[1]; Ende, M ^[2]

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1. New Jersey Medical School, Newark (United States)
2. Southside Regional Medical Center, Petersburg, PA (United States)

The authors have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over seventy percent of mice injected with HUCB survived 900 cGy or irradiation, which produced 100% deaths in the uninjected control animals. Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

• OSTI ID: 7013508
• Journal Information: Life Sciences; (United States), Journal Name: Life Sciences; (United States) Vol. 51:16; ISSN 0024-3205; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
GROWTH FACTORS
IRRADIATION
LETHAL IRRADIATION
MAMMALS
MAN
MATERIALS
MICE
MITOGENS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RADIOSENSITIVITY EFFECTS
RODENTS
SURVIVAL TIME
VERTEBRATES