16,16-dimethyl prostaglandin E/sub 2/ increases survival of murine intestinal stem cells when given before photon radiation

Journal Article · Tue Nov 01 00:00:00 EST 1983 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576222· OSTI ID:5073978

Hanson, W R; Thomas, C

A variety of prostaglandins (PG) protect the gastric and intestinal mucosa when given before damaging agents as absolute ethanol, acidified taurocholate, boiling water, or nonsteroidal anti-inflammatory agents (NSAI). A synthetic prostaglandin, 16,16-dimethyl PGE/sub 2/, shown to be cytoprotective at physiologic levels to the above agents was given to mice 1 h before or 15 min after /sup 137/Cs gamma(..gamma..) whole-body irradiation. The survival of intestinal stem cells measured by their ability to form in situ colonies of regenerating epithelium was increased stem cells measured by their ability to form in situ colonies of regenerating epithelium was increased when 16,16-dimethyl PGE/sub 2/ was given before but not after /sup 137/Cs ..gamma.. irradiation. The maximum degree of 16,16-dimethyl PGE/sub 2/-induced radioprotection was seen when the drug was given 1 h before irradiation. No radioprotection was seen when the interval between drug and irradiation was 3 h or longer. When the time between 16,16-dimethyl PGE/sub 2/ and irradiation was kept at 1 h, the degree of radioprotection was dependent on the PG drug dose. There was a steep rise in the number of surviving cells at low doses of PG. These results imply that tumors which secrete PGE/sub 2/ may in part be protected from the lethal effects of ionizing photon radiation.

• Research Organization: Rush Univ.-Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL
• OSTI ID: 5073978
• Journal Information: Radiat. Res.; (United States), Vol. 96:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
INTESTINES
BIOLOGICAL RADIATION EFFECTS
PROSTAGLANDINS
RADIOSENSITIVITY EFFECTS
STEM CELLS
CESIUM 137
COLONY FORMATION
GAMMA RADIATION
MICE
WHOLE-BODY IRRADIATION
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CESIUM ISOTOPES
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GASTROINTESTINAL TRACT
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals