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16,16-dimethyl prostaglandin E/sub 2/ induces radioprotection in Murine intestinal and hematopoietic stem cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3576574· OSTI ID:5265084
;

Exogenous prostaglandins (PGs) have been shown to protect gastrointestinal mucosa, liver, and pancreas from several injurious agents, including the PG inhibitor, indomethacin. Previous studies from this laboratory showed exogenous administration of 16,16-dimethyl (dm) PGE/sub 2/ also protected mouse intestinal stem cells from radiation injury. The present study extended that observation and demonstrated that PGs given to B6D2F1 mice 1 hr before irradiation increased the shoulder of the intestinal clonogenic cell survival curve. PGs increased the LD50/6 from 16.3 + 0.41 in controls to 20.25 + 0.55 Gy. The 16,16-dm PGE/sub 2/ increased the hematopoietic CFU-S survival in a qualitatively similar way. A large number of human tumors secrete a variety of PGs. Our results suggest that those tumors may be, in part, protected from radiation injury.

Research Organization:
Rush Univ., Chicago, IL
DOE Contract Number:
AC03-76SF00098
OSTI ID:
5265084
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 103:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BONE MARROW
COBALT 60
COBALT ISOTOPES
COLONY FORMATION
DIGESTIVE SYSTEM
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LETHAL DOSES
LETHAL RADIATION DOSE
MAMMALS
MICE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANS
PROSTAGLANDINS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
RODENTS
SOMATIC CELLS
STEM CELLS
SURVIVAL CURVES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES