Toxicological effects on mice following inhalation exposures to fluidized-bed coal combustor fly ash

Journal Article · Thu Dec 01 04:00:00 EST 1983 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(83)90115-9· OSTI ID:7012060

Kirchner, F R; Reilly, Jr, C A; Buchholz, D M; Pahnke, Jr, V A

Toxicological effects of exposure to reaerosolized fly ash from a fluidized-bed coal combustor were evaluated in mice following 500- and 1000-hr inhalation exposures. Alveolar macrophage function, organ histology, and hematopoiesis were assessed following 24-hr/day exposures in two 500-hr experiments. There was little mutagenicity detected by the Ames assay in the samples of the fly ash tested. The chemical characteristics of the fly ash were very similar to those of fly ash produced during conventional coal combustion. However, physical characterization revealed that fluidized-bed combustion fly ash was not fused as is commonly the case in conventionally combusted fly ash, and as a result had a very large surface area. The function of the alveolar macrophages of exposed mice was impaired, and there were significant changes in the histology of the lung, including cellular infiltration and hyperplasia of bronchiolar and alveolar epithelium. These changes are characteristic of pulmonary responses to chronic irritation of the lung.

• Research Organization: Argonne National Lab., IL
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 7012060
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 32:2; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMAL CELLS
ANIMALS
ASHES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
BIOLOGICAL PATHWAYS
BLOOD FORMATION
COMBUSTORS
CONNECTIVE TISSUE CELLS
FLUIDIZED-BED COMBUSTORS
FLY ASH
FUNCTIONS
HISTOLOGY
INHALATION
INTAKE
MACROPHAGES
MAMMALS
MICE
MUTAGEN SCREENING
PARTICLE SIZE
PATHOLOGICAL CHANGES
PHAGOCYTES
RESIDUES
RODENTS
SCREENING
SIZE
SOMATIC CELLS
VERTEBRATES
WASTES