Toxicological effects on mice following inhalation exposures to fluidized-bed coal combustor fly ash
Toxicological effects of exposure to fly ash from a fluidised-bed combustor were evaluated in mice following 500-1000 h inhalation exposures. There was little mutagenicity detected by the Ames assay of the fly ash. The chemical characteristics of the ash were very similar to those of fly ash produced during conventional coal combustion, but physical characterisation showed that the fluidised-bed ash was not fused as is the case with conventionally combusted ash, and as a result had a very large surface area. The function of the alveolar macrophages of exposed mice was impaired, and there were significant changes in the histology of the lung. These changes are characteristic of pulmonary responses to chronic irritation of the lung.
- OSTI ID:
- 6841323
- Journal Information:
- Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 32:2; ISSN ENVRA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOL WASTES
ANIMAL CELLS
ANIMALS
ASHES
BIOLOGICAL EFFECTS
BODY
CHEMICAL REACTIONS
COMBUSTION
COMBUSTION PRODUCTS
CONNECTIVE TISSUE CELLS
FLUIDIZED-BED COMBUSTION
FLY ASH
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
LUNGS
MACROPHAGES
MAMMALS
MICE
MUTAGEN SCREENING
ORGANS
OXIDATION
PARTICLE SIZE
PARTICLES
PARTICULATES
PHAGOCYTES
RESIDUES
RESPIRATORY SYSTEM
RODENTS
SCREENING
SIZE
SOMATIC CELLS
SURFACE AREA
SURFACE PROPERTIES
THERMOCHEMICAL PROCESSES
TOXICITY
VERTEBRATES
WASTES