Effects of heavy-atom salts on the luminescence properties of Tetrol I-1 on [alpha]-cyclodextrin/salt matrices
- Department of Chemistry, University of Wyoming, Laramie, Wyoming 82071 (United States)
Benzo([alpha])pyrene [B(a)P] is one of the most widely studied polyaromatic hydrocarbons. In the human body and in lower animals, B(a)P can become chemically bonded to DNA. Tetrols are the products obtained from the hydrolysis of B(a)P-DNA adducts. It has been proposed that the amount of tetrols detected in human body fluids can be used as a measure of the amount of B(a)P-DNA adducts present in the body. The effects of several heavy-atom salts on the solid-matrix fluorescence and phosphorescence properties of the tetrols were investigated. TINO[sub 3] and TIF were very useful in enhancing the room-temperature phosphorescence (RTP) of the tetrols. For tetrol I-1 on 1:1:8 [alpha]-cyclodextrin:TINO[sub 3]:NaNO[sub 3], the limit of detection was 0.38 femtomole/mg. The RTP approach with the 1:1:8 [alpha]-cyclodextrin:TINO[sub 3]:NaNO[sub 3] matrix would be useful for detecting subfemtomole quantities of the tetrols of B(a)P-DNA adducts from biological samples.
- DOE Contract Number:
- FG02-86ER13547
- OSTI ID:
- 7008826
- Journal Information:
- Applied Spectroscopy; (United States), Journal Name: Applied Spectroscopy; (United States) Vol. 48:6; ISSN 0003-7028; ISSN APSPA4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
Applied Studies
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
664200 -- Spectra of Atoms & Molecules & their Interactions with Photons-- (1992-)
74 ATOMIC AND MOLECULAR PHYSICS
AMBIENT TEMPERATURE
AMINES
AROMATICS
BENZOPYRENE
CHEMICAL BONDS
CHEMICAL EXPLOSIVES
CONDENSED AROMATICS
DNA
EXPLOSIVES
FLUORESCENCE
HYDROCARBONS
LUMINESCENCE
NITRO COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PHOSPHORESCENCE
SALTS
TETRYL