Electron microscopy examination of ventricles from hypertrophied hearts of copper deficient rats

Journal Article · Wed Feb 15 04:00:00 EST 1989 · FASEB Journal (Federation of American Societies for Experimental Biology); (USA)

OSTI ID:7005424

Medeiros, D M; Bagby, D; Ovecka, G; McCormick, R J ^[1]

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1. Univ. of Wyoming, Laramie (USA)

Male Long Evans rats were fed AIN-76 diets that were either copper adequate (8 mg/kg diet, n=6) or copper deficient (0.4 mg/Kg diet, n=6) from weaning until 8 weeks, thereafter. Copper deficiency was verified by decreased hematocrit and liver copper levels and increased heart weight in the copper deficient group. Left ventricular cardiac muscle was removed and processed from histological examination by transmission electron microscopy. In copper adequate rats the myocytes were usually separated by single rows of mitochondria with cristae in densely packed parallel arrays. In copper deficient rats, pockets of greatly proliferated mitochondria were observed between the muscle fibers. These mitochondria were enlarged vacuolized and contained fragmented cristae. Areas of poorly organized myofilaments were detected in the ventricles of copper deficient animals. Accumulation of glycogen and lipid droplets was apparent in these rats.

• OSTI ID: 7005424
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (USA), Journal Name: FASEB Journal (Federation of American Societies for Experimental Biology); (USA) Vol. 3:4; ISSN FAJOE; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
COPPER
DIET
ELECTRON MICROSCOPY
ELEMENTS
GLYCOGEN
HEART
LIPIDS
MAMMALS
METALS
MICROSCOPY
MITOCHONDRIA
MORPHOLOGICAL CHANGES
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
POLYSACCHARIDES
RATS
RODENTS
SACCHARIDES
TRANSITION ELEMENTS
TRANSMISSION ELECTRON MICROSCOPY
VERTEBRATES