Skip to main content
OSTI.GOVU.S. Department of Energy Office of Scientific and Technical Information
U.S. Department of Energy
Office of Scientific and Technical Information
 

The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content

Journal Article · · Am. J. Hum. Genet.; (United States)
OSTI ID:7005321
; ;
Cells from individuals with Cockayne syndrome (CS) are hypersensitive to the lethal effects of ultraviolet light (uv) and show a number of abnormal biochemical responses following uv-irradiation. Fujiwara et al. recently reported that the NAD contents of CS fibroblasts were lower than those of normal fibroblasts, and that addition of NAD to the cellular growth medium rectified most of the abnormal responses of CS cells to uv-irradiation. In our experiments, however, the cellular NAD contents of normal and CS fibroblasts were similar, and addition of NAD to the growth medium had no effect on the hypersensitivity of CS cells to uv-irradiation, nor did it restore the inability of CS cells to recover normal rates of DNA or RNA synthesis following uv-irradiation.
Research Organization:
MRC Cell Mutation Unit, University of Sussex, England
OSTI ID:
7005321
Journal Information:
Am. J. Hum. Genet.; (United States), Journal Name: Am. J. Hum. Genet.; (United States) Vol. 36:2; ISSN AJHGA
Country of Publication:
United States
Language:
English

Similar Records

Genetic complementation groups in cockayne syndrome
Journal Article · Wed Jul 01 00:00:00 EDT 1981 · Somatic Cell Genet.; (United States) · OSTI ID:5512240
Gamma-ray-enhanced reactivation of irradiated adenovirus in Xeroderma pigmentosum and Cockayne syndrome fibroblasts
Journal Article · Wed Jun 01 00:00:00 EDT 1983 · Radiat. Res.; (United States) · OSTI ID:5742746
Use of lymphoblastoid cell lines to evaluate the hypersensitivity to ultraviolet radiation in Cockayne syndrome
Journal Article · Tue May 01 00:00:00 EDT 1984 · J. Invest. Dermatol.; (United States) · OSTI ID:5707925

Related Subjects

550200 -- Biochemistry
560115* -- Radiation Effects on Biochemicals-- In Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHEMISTRY
COENZYMES
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
FIBROBLASTS
HEREDITARY DISEASES
MAMMALS
MAN
NAD
NUCLEOTIDES
ORGANIC COMPOUNDS
PRIMATES
RADIATION EFFECTS
RADIATIONS
SOMATIC CELLS
ULTRAVIOLET RADIATION
VERTEBRATES