Genetic complementation groups in cockayne syndrome
Journal Article
·
· Somatic Cell Genet.; (United States)
Skin fibroblasts from patients with cockayne syndrome (CS cell) exhibited marked ultraviolet (UV) sensitivity as measured by colony-forming ability. Further, recovery of semiconservative DNA synthesis following UV irradiation was absent in CS cells, as it is in xeroderma pigmentosum cells. We found that the rate of semiconservative DNA synthesis measured at 12 h after 12 J/m2 of UV irradiation had recovered to nearly normal levels in binuclear cells obtained by the fusion of CS strains CS3BE (GM 1856) and CS7SE (GM1428) and of CS3BE (GM1856) and CS1BE (GM1629), but not of C57SE (GM1428) and CS1BE (GM1629). These results indicate that there are at least two genetic complementation groups in CS.
- OSTI ID:
- 5512240
- Journal Information:
- Somatic Cell Genet.; (United States), Journal Name: Somatic Cell Genet.; (United States) Vol. 7:4; ISSN SCEGD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Failure of RNA synthesis to recover after UV irradiation: an early defect in cells from individuals with Cockayne's syndrome and xeroderma pigmentosum
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The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content
Journal Article
·
Wed Mar 31 23:00:00 EST 1982
· Cancer Res.; (United States)
·
OSTI ID:5440828
Ultraviolet light-induced chromosomal aberrations in cultured cells from Cockayne syndrome and complementation group C xeroderma pigmentosum patients: lack of correlation with cancer susceptibility
Journal Article
·
Mon Feb 29 23:00:00 EST 1988
· Am. J. Hum. Genet.; (United States)
·
OSTI ID:5168836
The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content
Journal Article
·
Wed Feb 29 23:00:00 EST 1984
· Am. J. Hum. Genet.; (United States)
·
OSTI ID:7005321
Related Subjects
550400 -- Genetics
550900 -- Pathology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGY
BIOSYNTHESIS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETICS
HEREDITARY DISEASES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGY
PATIENTS
RADIATIONS
RADIOSENSITIVITY
SOMATIC CELLS
SYNTHESIS
ULTRAVIOLET RADIATION
550900 -- Pathology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGY
BIOSYNTHESIS
COLONY FORMATION
CONNECTIVE TISSUE CELLS
DISEASES
DNA
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETICS
HEREDITARY DISEASES
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGY
PATIENTS
RADIATIONS
RADIOSENSITIVITY
SOMATIC CELLS
SYNTHESIS
ULTRAVIOLET RADIATION