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Effect of subchronic administration of methyl parathion on in vivo protein synthesis in pregnant rats and their conceptuses

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
; ; ;

Pregnant rats received daily po doses of the organophosphate methyl parathion (MPTH) from Day 6 through Day 15 or 19 of gestation at doses causing no (1.0 mg/kg) or minimal (1.5 mg/kg) signs of maternal toxicity. Following the dose of MPTH on Day 15 or 19, in vivo protein synthesis was measured 0.5, 1.0, and 2.0 hr after sc injection of L-(1-/sup 14/C)valine at a dose of 5 microCi/mmol/100 g body wt. The specific activity of (/sup 14/C)valine in the free amino acid pool and protein bound pool was significantly reduced in various regions of maternal brain and in maternal viscera, placenta, and whole embryos (Day 15), and in fetal brain and viscera (Day 19). The inhibitory effect of MPTH on net protein synthesis was dose dependent, greater on Day 19 than 15 of gestation and more pronounced in fetal than in maternal tissues.

Research Organization:
Department of Pharmacology and Toxicology, Michigan State University, East Lansing
OSTI ID:
7003214
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 72:3; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

550201 -- Biochemistry-- Tracer Techniques
550801 -- Morphology-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
EMBRYOS
ESTERS
INSECTICIDES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
METABOLISM
ORAL ADMINISTRATION
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARATHION
PESTICIDES
PREGNANCY
THIOPHOSPHORIC ACID ESTERS
TOXICITY
TRACER TECHNIQUES
VALINE