MR characterization of brain and brain tumor response to radiotherapy

Journal Article · Fri Jul 01 04:00:00 EDT 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90368-9· OSTI ID:7001909

Houdek, P V; Landy, H J; Quencer, R M; Sattin, W; Poole, C A; Green, B A; Harmon, C A; Pisciotta, V; Schwade, J G

This paper describes our experience in using the T1 and T2 relaxation times for quantitative evaluation of brain and brain tumor response to radiation therapy. Twenty-two computed T1 and 22 computed T2 images were obtained from 66 routine inversion-recovery and spin-echo magnetic resonance (MR) brain scans. The relaxation times of the brain tissues, determined from the computed images, were examined as a function of the absorbed dose. Statistical evaluation of the results showed no significant difference between the relaxation times of irradiated and not irradiated tissues, including tumor and normal white matter. Influence of the magnetic field strength and imaging techniques on the computed T1 and T2 values was confirmed. We conclude that the relaxation time values, as obtained today using conventional MR scanner and standard software, are not specific enough to warrant a correct assessment of the acute radiation effect on the brain tissues.

• Research Organization: Univ. of Miami School of Medicine, FL (USA)
• OSTI ID: 7001909
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 15:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550600* -- Medicine
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
IMAGES
MAGNETIC RESONANCE
MEDICINE
NEOPLASMS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
RESONANCE
SPIN ECHO
THERAPY