Tissue characterization of brain tumors during and after pion radiation therapy

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Magnetic Resonance Imaging; (USA)

DOI:https://doi.org/10.1016/0730-725X(90)90057-9· OSTI ID:6420477

Boesiger, P; Greiner, R; Schoepflin, R E; Kann, R; Kuenzi, U ^[1]

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1. Univ. of Zurich (Switzerland)

Negative Pi-mesons (pions) are applied at the Paul Scherrer Institute in the radiotherapy of highly malignant gliomas using a dose escalation program. The therapy effects of 7 randomly selected patients were followed up by 62 MRI examinations. The quantification of the effects is based on the relaxation times T1 and T2, which are acquired by a new designed multi-echo multiple saturation recovery imaging technique. As a summary of the results, roughly two reaction types are observed. For both types the relaxation times increase up to two to three months after the radiation therapy. Then in one type (two patients) the T1 and T2 values of the tumors, and of the edemas surrounding the tumors, further increase, indicating an unfavorable prognosis. In the other type (five patients) the relaxation times drop down towards, or even below, their initial values, reflecting the onset of the reparation processes in the tissue. This later behavior reflects an at least temporary control of the disease; that is, the short term prognosis for these patients is more favorable. It further can be concluded, with respect to our MR parameters, that the radiotolerance of healthy brain tissue is much higher than that of malignant glioma tissue, despite the fact that these tumors are very seldom definitively radiosensible.

• OSTI ID: 6420477
• Journal Information: Magnetic Resonance Imaging; (USA), Journal Name: Magnetic Resonance Imaging; (USA) Vol. 8:4; ISSN MRIMD; ISSN 0730-725X
• Country of Publication: United States
• Language: English

Related Subjects

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560151 -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BOSONS
BRAIN
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTARY PARTICLES
GLIOMAS
HADRONS
MEDICINE
MESONS
NEOPLASMS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MEDICINE
ORGANS
PATIENTS
PIONS
POST-IRRADIATION EXAMINATION
PSEUDOSCALAR MESONS
RADIATION EFFECTS
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY