Scintigraphic detection of regional disruption of adrenergic neurons in the heart

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Am. Heart J.; (United States)

DOI:https://doi.org/10.1016/0002-8703(88)90251-7· OSTI ID:7001434

Sisson, J C; Lynch, J J; Johnson, J; Jaques, S Jr; Wu, D; Bolgos, G; Lucchesi, B R; Wieland, D M

Experiments were designed to detect regional disruptions of adrenergic neurons in the hearts of living dogs. The neuron disruption was achieved by the application of phenol to the epicardium of the left ventricle. Evidence for denervation was the reduction in endogenous norepinephrine (NE) concentrations in the myocardium beneath the region of phenol treatment and toward the apex. Radiolabeled meta-iodobenzylguanidine (MIBG) acts as an analog of NE and as such is concentrated in adrenergic nerve terminals. Following phenol application, MIBG labeled with /sup 125/I was found, 20 hours after injection, to be distributed within myocardium in patterns comparable to those of NE. However, left stellectomy did not alter the distributions of NE or /sup 125/I-MIBG in the myocardium and apparently did not disrupt adrenergic innervation. MIBG labeled with /sup 123/I enabled scintigraphic images of heart neurons in the living dog 3 and 20 hours after injection; these images portrayed the regions of adrenergic neuron disruption caused by phenol treatment. Concentrations of thallium-201 depicted on scintigraphic image and of triphenyltetrazolium observed on in vitro staining demonstrated no myocardial injury. Thus, scintigraphy with /sup 123/I-MIBG will display regional adrenergic denervations in the heart.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor (USA)
• OSTI ID: 7001434
• Journal Information: Am. Heart J.; (United States), Journal Name: Am. Heart J.; (United States) Vol. 116; ISSN AHJOA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560300 -- Chemicals Metabolism & Toxicology
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMAL CELLS
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MUSCLES
MYOCARDIUM
NERVE CELLS
NEUROREGULATORS
NORADRENALINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PHENOLS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SENSITIVITY
SOMATIC CELLS
SYMPATHOMIMETICS
THALLIUM 201
THALLIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES