Measuring acute changes in adrenergic nerve activity of the heart in the living animal

Journal Article · Sun Mar 31 23:00:00 EST 1991 · American Heart Journal; (USA)

DOI:https://doi.org/10.1016/0002-8703(91)90671-4· OSTI ID:5799062

Sisson, J C; Bolgos, G; Johnson, J ^[1]

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1. Univ. of Michigan, Ann Arbor (USA)

Changes in the function of the adrenergic neurons of the heart may be important indicators of the adaptations of an animal to physiologic stress and disease. Rates of loss of norepinephrine (NE) from the heart were considered to be proportional to NE secretion and to adrenergic function. In rat hearts, yohimbine induced almost identical increases in rates of loss of {sup 3}H-NE and of {sup 125}I-metaiodobenzylguanidine (MIBG), a functional analog of NE. Clonidine induced decreases in rates of loss of {sup 3}H-NE that were also mimicked by those of {sup 125}I-MIBG. In the dog heart, pharmacologically-induced increases and decreases in rates of loss of {sup 123}I-MIBG could be measured externally; these values were similar to those obtained for {sup 125}I-MIBG in the rat heart. Thus acute changes in the adrenergic neuron activity can be measured in the living heart. The method is applicable to man in determining the capacity of the adrenergic system to respond to provocative challenges.

• OSTI ID: 5799062
• Journal Information: American Heart Journal; (USA), Journal Name: American Heart Journal; (USA) Vol. 121:4 Pt 1; ISSN AHJOA; ISSN 0002-8703
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BIOLOGICAL FUNCTIONS
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
HEART
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
METABOLISM
NERVE CELLS
NEUROREGULATORS
NORADRENALINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PHYSIOLOGY
RADIOISOTOPES
RATS
RODENTS
SECRETION
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES