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Myocardial localization of radiolabeled meta-iodobenzylguanidine: an interspecies comparison

Conference · · HHS Publ. (FDA) (U.S.); (United States)
OSTI ID:5714312
; ; ; ; ;
The myocardial localization of radiolabeled meta-iodobenzylguanidine (mIBG), an anlog of the adrenergic neuronal blocking agent-guanethidine, was analyzed in various animal species and man. Tissue distribution studies were performed in rats, dogs, and monkeys using /sup 125/I-mIBG. An in-vivo quantification method was used to determine human myocardial uptake of /sup 123/I-mIBG. Although high quality images of the human heart were obtained with /sup 123/I-mIBG, the quantification data indicates that the human myocardial localization of this agent was significantly lower than that abserved in the animals. If this observation does not reflect an alteration in it's proposed mechanism of localization, this agent may prove useful for analyzing the adrenergic state of the myocardium.
Research Organization:
Univ. of Michigan Medical Center, Ann Arbor
OSTI ID:
5714312
Report Number(s):
CONF-801082-
Conference Information:
Journal Name: HHS Publ. (FDA) (U.S.); (United States) Journal Volume: 81-8166
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
560171 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DOGS
ELECTRON CAPTURE RADIOISOTOPES
GUANIDINES
HEART
IN VIVO
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
MAMMALS
MONKEYS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SCINTISCANNING
TISSUE DISTRIBUTION
UPTAKE
VERTEBRATES