Myocardial imaging with a radioiodinated norepinephrine storage analog

Journal Article · Thu Jan 01 04:00:00 EST 1981 · J. Nucl. Med.; (United States)

OSTI ID:6689199

Wieland, D M; Brown, L E; Rogers, W L; Worthington, K C; Wu, J L; Clinthorne, N H; Otto, C A; Swanson, D P; Beierwaltes, W H

Meta-iodobenzylguanidine (M-IBG), an iodinated aromatic analog of the hypotensive drug guanethidine, localizes in the heart of the rat, dog, and rhesus monkey. A comparative study of tissue distribution in the dog has been performed with five myocardiophilic agents: thallium-201, I-125 16-iodohexadecanoic acid, H-3 norepinephrine, C-14 guanethidine and I-125 M-IBG. The last two compounds give heart concentrations and heart-to-blood concentration ratios similar to those of thallium-201. Planar and tomographic images of the hearts of the dog and rhesus monkey were obtained using I-131 or I-123 labeled M-IBG. Blocking studies with reserpine suggest that a major component of myocardial retention of M-IBG is sequestration within the norepinephrine storage vesicles of the adrenergic nerves. The localization of M-IBG in other organs with rich sympathetic innervation and the relative insensitivity of myocardial uptake to a wide range of loading doses lend additional support for a neuronal mode of retention.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor
• DOE Contract Number: EY-76-S-02-2031
• OSTI ID: 6689199
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:1; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BODY
CARBON 14
CARBON ISOTOPES
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISTRIBUTION
DOGS
DOSES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
GUANIDINES
HEART
HEAVY NUCLEI
HYDROGEN ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MACACUS
MAMMALS
MONKEYS
MUSCLES
MYOCARDIUM
NERVES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RETENTION
RODENTS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION
TRITIUM
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES