Imaging the primate adrenal medulla with (/sup 123/I) and (/sup 131/I) metaiodobenzylguanidine: concise communication
An evaluation of radioiodinated meta-iodobenzylguanidine (m-IBG) as an adrenomedullary imaging agent is reported in 15 rhesus monkeys. Scintiscans of the monkey adrenal medulla have been obtained with (/sup 123/I)- and (m-/sup 131/)IBG at 2 to 6 days after injection. The imaging superiority of m-IBG over its positional isomer, para-iodobenzylguanidine (p-IBG), is documented in both dogs and monkeys. Administration of reserpine, a depletor of catecholamine stores, markedly lowers the (m-/sup 131/I)-IBG content of the dog adrenal medulla, but the adrenergic blocking agents phenoxybenzamine and propanolol have no effect. Subcellular fractionation of the dog's adrenal medullae reveals that m-IBG is sequestered mainly in the chromaffin storage granules. The results of this study suggest that radioiodinated m-IBG, previously reported to image the primate myocardium, also merits evaluation as a clinical radiopharmaceutical for the adrenal medulla.
- Research Organization:
- Univ. of Michigan, Ann Arbor
- DOE Contract Number:
- EY-76-S-02-2031
- OSTI ID:
- 6582513
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 22:4
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
ADRENAL GLANDS
SCINTISCANNING
IODINE 123
DIAGNOSTIC USES
IODINE 131
BIOLOGICAL PATHWAYS
COMPARATIVE EVALUATIONS
DOGS
GUANIDINES
IMAGES
MACACUS
PERFORMANCE TESTING
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS
TISSUE DISTRIBUTION
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBONIC ACID DERIVATIVES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
MONKEYS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TESTING
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
551001 - Physiological Systems- Tracer Techniques