Human absorbed dose calculations for iodine-131 and iodine-123 labeled meta-iodobenzyl-guanidine (mIBG): a potential myocardial and adrenal medulla imaging agent

Conference · Mon Jun 01 04:00:00 EDT 1981 · HHS Publ. (FDA) (U.S.); (United States)

OSTI ID:5870145

Swanson, D P; Carey, J E; Brown, L E; Kline, R C; Wieland, D M; Thrall, J H; Beierwaltes, W H

Tissue distribution studies with radiolabeled meta-iodobenzyl-guanidine (mIBG), an analog of the adrenergic neuronal blocking agent-guanethidine, suggest that this radiotracer may be useful for both myocardial imaging (labeled with I-123) and adrenal medulla imaging (labeled with I-131). Total body elimination was determined by whole body counting (well-type ionization chamber) of rats administered /sup 131/I-mIBG and time-activity tissue distribution data was obtained in dogs using /sup 125/I-mIBG. Using the MIRD formalism, researchers have estimated the human absorbed dose from /sup 131/I-mIBG, radionuclidically pure /sup 123/I-mIBG, and /sup 1/''/sup 3/I-mIBG contaminated with 4.8% /sup 125/I-mIBG (based on /sup 123/I radionuclidic purity specification of 1.4% I-125 at calibration). The largest absorbed dose from /sup 131/I-mIBG was delivered to the adrenals. For pure /sup 123/I-mIBG the largest absorbed dose was delivered to the thyroid (unblocked). The /sup 125/I contamination increased the absorbed dose to the adrenal medulla by a factor of 3.5.

• Research Organization: Univ. of Michigan Medical Center, Ann Arbor
• OSTI ID: 5870145
• Report Number(s): CONF-801082-
• Conference Information: Journal Name: HHS Publ. (FDA) (U.S.); (United States) Journal Volume: 81-8166
• Country of Publication: United States
• Language: English

Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560171* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Man-- (-1987)
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBONIC ACID DERIVATIVES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISTRIBUTION
DOGS
DOSES
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
GUANIDINES
HEART
HOURS LIVING RADIOISOTOPES
IMPURITIES
INTERMEDIATE MASS NUCLEI
INTERNAL IRRADIATION
IODINE 123
IODINE 125
IODINE 131
IODINE ISOTOPES
IRRADIATION
ISOTOPES
KIDNEYS
MAMMALS
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
RADIATION DOSES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RATS
RODENTS
SCINTISCANNING
THYROID
TISSUE DISTRIBUTION
USES
VERTEBRATES