Portrayal of pheochromocytoma and normal human adrenal medulla by m-(/sup 123/I)iodobenzylguanidine: concise communication
The radiopharmaceutical m-(/sup 131/I)iodobenzylguanidine (I-131 MIBG), which is readily taken up by adrenergic vesicles, produces scintigraphic images of pheochromocytomas in man but rarely visualizes normal adrenal glands. Iodine-123 has many potential advantages over I-131 as a radiolabel for MIBG, including shorter half-life, freedom from beta emissions, and increased gamma-camera efficiency. In this study, diagnostic doses of MIBG labeled with I-131 and I-123, with nearly equivalent radiation dosimetry, were compared as imaging agents in eight patients with known or suspected pheochromocytoma. Images of superior quality were obtained with I-123 MIBG. In addition, the normal adrenal medullae were visualized on the I-123 MIBG scintigrams in six out of eight patients.
- Research Organization:
- Univ. of Michigan, Ann Arbor
- DOE Contract Number:
- AC02-76EV02031
- OSTI ID:
- 6816859
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:4
- Country of Publication:
- United States
- Language:
- English
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ADRENAL GLANDS
SCINTISCANNING
IODINE 123
NEOPLASMS
RADIOPHARMACEUTICALS
COMPARATIVE EVALUATIONS
GUANIDINES
PATIENTS
BETA DECAY RADIOISOTOPES
BODY
CARBONIC ACID DERIVATIVES
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
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HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
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LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
RADIOISOTOPE SCANNING
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550601* - Medicine- Unsealed Radionuclides in Diagnostics