Stage II endometrial carcinoma. Results and complications of a combined radiotherapeutic-surgical approach

Journal Article · Fri Apr 15 04:00:00 EDT 1988 · Cancer (Philadelphia); (United States)

DOI:https://doi.org/10.1002/1097-0142(19880415)61:8<1528::AID-CNCR2820610808>3.0.CO;2-9· OSTI ID:6998493

Larson, D M; Copeland, L J; Gallager, H S; Kong, J P; Wharton, J T; Stringer, C A

Since one third of the patients with Stage II endometrial carcinoma have occult extrauterine pelvic metastases at diagnosis, adequate treatment must include the pelvic lymph nodes and parametria. Eighty-three patients with Stage II endometrial carcinoma were treated between January 1964 and December 1983. Sixty-nine patients (83%) received combined whole-pelvic irradiation and surgery, five (6%) had surgery alone and nine (11%) had radiotherapy alone. Five-year actuarial survival rates were 67%, 60%, and 38%, respectively. No pelvic recurrence occurred in the 69 patients who received the combined therapy, and there was no vaginal recurrence in the 80 patients treated with intracavity radium. There was a significantly lower incidence of pelvic lymph node metastases (P = 0.03) in patients treated with preoperative irradiation. The median time to recurrence was 17 months, with 67% of the recurrences diagnosed before 2 years, and 88% within 5 years. Ten patients (12%) incurred severe complications and three died as a result. Whole-pelvic irradiation, intracavity radium, and hysterectomy are effective treatment for occult pelvic and vaginal disease.

• Research Organization: Univ. of Texas M. D. Anderson Hospital and Tumor Institute, Houston (USA)
• OSTI ID: 6998493
• Journal Information: Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 61:8; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALKALINE EARTH METALS
BODY
CARCINOMAS
DISEASES
ELEMENTS
FEMALE GENITALS
MEDICINE
METALS
METASTASES
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIOLOGY
RADIOTHERAPY
RADIUM
SURGERY
SURVIVAL CURVES
THERAPY
UTERUS