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Randomized study of preoperative radiation and surgery or irradiation alone in the treatment of Stage IB and IIA carcinoma of the uterine cervix

Conference · · Cancer; (United States)
OSTI ID:5220200
; ; ;

A prospective randomized study in selected patients with Stage IB and IIA carcinoma of the uterine cervix was carried out. Patients were randomized to be treated with 1) irradiation alone consisting of 1000 rad whole pelvis, additional 4000 rads to the parametria with a step wedge midline block, and two intracavitary insertions for 7500 mgh; and 2) irradiation and surgery, consisting of 2000 rad whole pelvis irradiation, one intracavitary insertion for 5000 to 6000 mgh followed in two to six weeks later by a radical hysterectomy with pelvic lymphadenectomy. The five-year, tumor-free actuarial survival for Stage IB patients treated with radiation was 87% and with preoperative radiation and surgery 82%. In Stage IIA, the actuarial five-year survival NED was 57% for the irradiation alone group and 71% for the patients treated with preoperative radiation and radical hysterectomy. Major complications of therapy were slightly higher in the patients trated with radiation alone (9.4%, consisting of one recto-vaginal fistula and one vesico-vaginal fistula and a combined recto-vesico-vaginal fistula in another patient). In the preoperative radiation group, only two ureteral strictures (4.1%) were noted. The present study shows no significant difference in therapeutic results or morbidity for invasive carcinoma of the uterine cervix Stage IB or IIA treated with irradiation alone or combined with a radical hysterectomy.

Research Organization:
Mallinckrodt Inst. of Radiology, St. Louis, MO
OSTI ID:
5220200
Journal Information:
Cancer; (United States), Journal Name: Cancer; (United States) Vol. 45:11; ISSN CANCA
Country of Publication:
United States
Language:
English

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550603 -- Medicine-- External Radiation in Therapy-- (1980-)
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
BODY AREAS
CARCINOMAS
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIGESTIVE SYSTEM
DISEASES
ELEMENTARY PARTICLES
ENERGY RANGE
EXTERNAL IRRADIATION
FEMALE GENITALS
FISTULAE
GASTROINTESTINAL TRACT
IMPLANTS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTERNAL IRRADIATION
INTESTINES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LARGE INTESTINE
LOCAL IRRADIATION
MASSLESS PARTICLES
MEDICINE
MEV RANGE
MEV RANGE 10-100
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
PHOTONS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RECTUM
SIDE EFFECTS
SURGERY
THERAPY
URINARY TRACT
UTERUS
YEARS LIVING RADIOISOTOPES