Irradiation alone or in combination with surgery in stage IB and IIA carcinoma of the uterine cervix

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Cancer; (United States)

OSTI ID:6210174

Perez, C A ^[1]; Breaux, S; Askin, F; Camel, H M; Powers, W E

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1. Washington Univ., St. Louis, MO

This is a report of a nonrandomized comparison of treatment results of 244 patients with stage IB carcinoma of the uterine cervix treated by radiation alone and 92 treated with preoperative radiation and surgery and 77 patients with stage IIA treated by radiation alone and 24 treated with a combination of radiation and surgery. The techniques or irradiation and types of operation are described in detail. The five-year tumor free actuarial survival for the patients with stage IB treated either with irradiation alone or combined with surgery was approximately 85% and the ten-year survival, 78%. Of the 24 patients treated with irradiation and surgery, there were two parametrial recurrences combined with distant metastasis (8.2%). There was no significant difference in the survival or recurrence rate of the patients treated with either method. In the group treated with combined therapy, patients with stage IB who showed evidence of microscopic residual tumor after irradiation had a failure rate of approximately 42% (8/18) in contrast to only 8.6% (6/70) in those with negative specimens. In stage IIA there were three failures in eight patients with residual tumor in the specimen in contrast to only two of 16 with negative specimens (12.5%). Major complications were comparable in both groups (radiation alone approximately 8.7% and irradiation combined with surgery approximately 14%); the difference is not statistically significant. The most frequent minor complication in patients treated with radiation alone was vaginal fibrosis (30 patients--9%) or vaginal vault necrosis (10 patients--3%).

• OSTI ID: 6210174
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:3; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
EXPERIMENTAL DATA
GASTROINTESTINAL TRACT
GRAPHS
INFORMATION
ISOLATED VALUES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURGERY
SURVIVAL TIME
THERAPY
UROGENITAL SYSTEM DISEASES