Effects of irradiation of mixed muellerian tumors of the uterus. [Complications following external and internal radiotherapy and surgery]

Journal Article · Sun Apr 01 04:00:00 EST 1979 · Cancer; (United States)

OSTI ID:6252538

Perez, C A ^[1]; Askin, F; Baglan, R J; Kao, M S; Kraus, F T; Perez, B M; Williams, C F; Weiss, D

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1. Mallinckrodt Inst. of Radiology, St. Louis, MO

A retrospective study of 54 patients with histologically proven malignant mixed muellerian tumors of the uterus was undertaken with main emphasis on the evaluation of the effects of irradiation on pelvic tumor control. The tumors were staged according to the FIGO classification for endometrial carcinoma and 24 were classified as Stage I, 10 as Stage II, 13 as Stage III, and seven as Stage IV. Patients with Stage I and II were treated with surgery alone, preoperative intracavitary irradiation, or preoperative combination of intracavitary and external irradiation. Five patients with Stage III and IV were treated with surgery alone, two were treated with a combination of irradiation and surgery, and 11 with radiation alone. None of these patients survived. In seven patients showing no residual tumor in the uterine specimen after irradiation, no pelvic failures were noted, whereas seven of 17 (41.2%) with residual tumor developed pelvic recurrences. In patients with Stage I treated with surgery alone, three out of six recurred in the pelvis whereas only three of 17 (17%) receiving preoperative irradiation developed pelvic recurrences. However, in Stage II six of eight patients treated with preoperative irradiation failed in the pelvis. Correlation with the doses of irradiation given to the uterus or the pelvic lymph nodes indicate that with doses below 5000 rads a significantly higher number of pelvic recurrences take place, whereas these are uncommon with doses over 6000 rads. It is suggested that patients with Stage I and II malignant mixed muellerian tumors of the uterus should be treated with preoperative radiation and total hysterectomy with bilateral salpingo-oophorectomy. Patients with more advanced disease have extremely poor prognosis and should be treated with radiation therapy alone. This tumor has a high propensity to spread through lymphatics and hematogenous metastases are seen in approximatly 75% of the patients.

• OSTI ID: 6252538
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:4; ISSN CANCA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CESIUM 137
CESIUM ISOTOPES
COBALT 60
COBALT ISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
EXTERNAL IRRADIATION
FEMALE GENITALS
FEMALES
FRACTIONATED IRRADIATION
GASTROINTESTINAL TRACT
IMPLANTS
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTERNAL IRRADIATION
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOCAL IRRADIATION
LUNGS
MALFORMATIONS
MAMMALS
MAN
MEDICINE
METALS
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
PNEUMONIA
PRIMATES
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RADIUM
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SIDE EFFECTS
SMALL INTESTINE
SURGERY
THERAPY
TIME DEPENDENCE
UTERUS
VEINS
VERTEBRATES
WOMEN
YEARS LIVING RADIOISOTOPES