Modification of the hypoxic fraction of a xenografted human colon tumor by differentiation-inducing agents
Journal Article
·
· JNCI, J. Natl. Cancer Inst.; (United States)
Xenografted tumors were produced in nude mice by injection of HCT-15 human colon tumor cells. The hypoxic fractions of control tumors as determined from x-ray survival curves were approximately 18%. Other tumors were treated (every day X 9) with daily injections of N-methylformamide (150 mg/kg) or sodium butyrate (2,000 mg/kg). For both agents, it was found that the hypoxic fractions were less than 0.05% and less than 1.7%, respectively. These data indicate that selected differentiation-inducing agents could be of value for treatment of human solid tumors that contain hypoxic cells.
- Research Organization:
- Rhode Island Hospital, Providence (USA)
- OSTI ID:
- 6993715
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 80:6; ISSN JJIND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550600 -- Medicine
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BODY
CELL DIFFERENTIATION
CHEMOTHERAPY
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
LARGE INTESTINE
MAMMALS
MICE
NONMETALS
ORGANS
OXYGEN
RADIATIONS
RODENTS
SURVIVAL CURVES
THERAPY
TUMOR CELLS
VERTEBRATES
X RADIATION
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMAL CELLS
ANIMALS
ANOXIA
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BODY
CELL DIFFERENTIATION
CHEMOTHERAPY
DIGESTIVE SYSTEM
DRUGS
ELECTROMAGNETIC RADIATION
ELEMENTS
EXPERIMENTAL NEOPLASMS
GASTROINTESTINAL TRACT
INTESTINES
IONIZING RADIATIONS
LARGE INTESTINE
MAMMALS
MICE
NONMETALS
ORGANS
OXYGEN
RADIATIONS
RODENTS
SURVIVAL CURVES
THERAPY
TUMOR CELLS
VERTEBRATES
X RADIATION