Response of a human colon adenocarcinoma (DLD-1) to x irradiation and mitomycin C in vivo
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
- Roger Williams General Hospital, Providence, RI
Mice hosting a heterogeneous human colon xenograft tumor produced by subcutaneous injection of the DLD-1 tumor cell line were treated either with x irradiation alone, with mitomycin C alone (4 mg/kg), or with x irradiation given two hours after intraperitoneal injection of mitomycin C (4 mg/kg). Radiation alone produced a dose dependent delay in the time needed for tumors to regrow to twice their size at the time of irradiation, and in the mice receiving mitomycin C plus x irradiation, an additional growth delay equivalent to that produced by 3 to 3.5 Gy of x rays was seen at all x ray dose levels. As the DLD-1 tumor xenografts do not appear to possess a significant hypoxic fraction, we conclude that the two agents are acting in a simple additive cytotoxic manner by the killing of oxic tumor cells.
- OSTI ID:
- 5744268
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 9:8; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effects of mitomycin C alone and in combination with X-rays on EMT6 mouse mammary tumors in vivo
Radiosensitizing and cytotoxic properties of mitomycin C in a C3H mouse mammary carcinoma in vivo
Modification of the hypoxic fraction of a xenografted human colon tumor by differentiation-inducing agents
Journal Article
·
Sat Oct 01 00:00:00 EDT 1983
· J. Natl. Cancer Inst.; (United States)
·
OSTI ID:6742990
Radiosensitizing and cytotoxic properties of mitomycin C in a C3H mouse mammary carcinoma in vivo
Journal Article
·
Thu Jan 31 23:00:00 EST 1991
· International Journal of Radiation Oncology, Biology and Physics; (USA)
·
OSTI ID:5838666
Modification of the hypoxic fraction of a xenografted human colon tumor by differentiation-inducing agents
Journal Article
·
Wed May 18 00:00:00 EDT 1988
· JNCI, J. Natl. Cancer Inst.; (United States)
·
OSTI ID:6993715
Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
CELL KILLING
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
MAN
MICE
MITOMYCIN
NEOPLASMS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SUBCUTANEOUS INJECTION
TUMOR CELLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
CELL KILLING
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
INJECTION
INTAKE
IONIZING RADIATIONS
MAMMALS
MAN
MICE
MITOMYCIN
NEOPLASMS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RODENTS
SUBCUTANEOUS INJECTION
TUMOR CELLS
VERTEBRATES
X RADIATION