Fluorocarbon-23 measure of cat cerebral blood flow by nuclear magnetic resonance

Journal Article · Mon Jan 01 04:00:00 EST 1990 · Stroke; (USA)

DOI:https://doi.org/10.1161/01.STR.21.1.100· OSTI ID:6993163

Ewing, J R; Branch, C A; Fagan, S C; Helpern, J A; Simkins, R T; Butt, S M; Welch, K M ^[1]

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1. Henry Ford Hospital, Detroit, MI (USA)

We employed fluorocarbon-23 (trifluoromethane) as a nuclear magnetic resonance gaseous indicator of cerebral blood flow in seven cats. Pulsed inhalation of this indicator and switching between two coils allowed the acquisition of both an arterial input and a cerebral response function, making possible multicompartmental curve fits to cerebral uptake and clearance data. The brain:blood partition coefficient for trifluoromethane was 0.9 for both gray and white matter. Fast-compartment blood flows were normal and showed appropriate CO{sub 2} reactivity. Slow-compartment blood flows did not demonstrate CO{sub 2} reactivity, probably because cranial as well as white-matter blood flows were lumped together in the slow compartment. Although cerebral blood flow was stable during administration of 60% trifluoromethane, the compound did prove to be a mild cardiac sensitizer to epinephrine in five cats.

• OSTI ID: 6993163
• Journal Information: Stroke; (USA), Journal Name: Stroke; (USA) Vol. 21:1; ISSN SJCCA; ISSN 0039-2499
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CATS
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
CHALCOGENIDES
FLUORINE 23
FLUORINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RESONANCE
SECONDS LIVING RADIOISOTOPES
SOLUBILITY
TRACER TECHNIQUES
VERTEBRATES