Cerebral blood flow measured by NMR indicator dilution in cats

Journal Article · Wed Feb 01 04:00:00 EST 1989 · Stroke; (United States)

DOI:https://doi.org/10.1161/01.STR.20.2.259· OSTI ID:6278792

Ewing, J R; Branch, C A; Helpern, J A; Smith, M B; Butt, S M; Welch, K M

We developed techniques to assess the utility of a nuclear magnetic resonance (NMR) indicator for cerebral blood flow studies in cats, using Freon-22 for the first candidate. A PIN-diode-switched NMR experiment allowed the acquisition of an arterial as well as a cerebral fluorine-19 signal proportional to concentration vs. time in a 1.89 T magnet. Mean +/- SD blood:brain partition coefficients for Freon-22 were estimated at 0.93 +/- 0.08 for gray matter and 0.77 +/- 0.12 for white matter. Using maximum-likelihood curve fitting, estimates of mean +/- SD resting cerebral blood flow were 50 +/- 19 ml/100 g-min for gray matter and 5.0 +/- 2.0 ml/100 g-min for white matter. Hypercapnia produced the expected increases in gray and white matter blood flow. The physiologic effects of Freon-22, including an increase in cerebral blood flow itself with administration of 40% by volume, may limit its use as an indicator. Nevertheless, the NMR techniques described demonstrate the feasibility of fluorine-19-labeled compounds as cerebral blood flow indicators and the promise for their use in humans.

• Research Organization: Henry Ford Hospital, Detroit, MI (USA)
• OSTI ID: 6278792
• Journal Information: Stroke; (United States), Journal Name: Stroke; (United States) Vol. 20:2; ISSN SJCCA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BLOOD FLOW
BLOOD-BRAIN BARRIER
BODY
BRAIN
CATS
CENTRAL NERVOUS SYSTEM
DIAGNOSTIC TECHNIQUES
FLUORINE 19
FLUORINE ISOTOPES
FREONS
HALOGENATED ALIPHATIC HYDROCARBONS
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
MAMMALS
NERVOUS SYSTEM
NMR IMAGING
NUCLEAR MAGNETIC RESONANCE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
RESONANCE
STABLE ISOTOPES
TRACER TECHNIQUES
VERTEBRATES