Effect of stimulation of trigeminal ganglion on regional cerebral blood flow in cats

Journal Article · Sat Aug 01 04:00:00 EDT 1987 · American Journal of Physiology; (USA)

OSTI ID:5032802

Goadsby, P J; Duckworth, J W ^[1]

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1. Prince Henry Hospital, Little Bay (Australia)

Regional cerebral blood flow was studied in the cat, with and without trigeminal ganglion stimulation, by the intravenous injection of the tracer ({sup 14}C)iodoantipyrine and subsequent regional brain dissection. Electrical activation of the trigeminal ganglion led to a selective increase in regional blood flow in the frontal and parietal cortex that was bilateral without change in the posterior cortex, deep cerebral nuclei, white matter, or brain stem. Unilateral intracranial section of the facial nerve blocked the response in the ipsilateral frontal and parietal cortex, whereas bilateral facial nerve section blocked the contralateral frontal cortical response. The contralateral parietal cortical increase in blood flow was not affected by facial nerve section and may thus represent the result of metabolic activation of sensory cortex.

• OSTI ID: 5032802
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:2; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ANTIPYRETICS
ANTIPYRINE
AZOLES
BIOELECTRICITY
BLOOD FLOW
BODY
BRAIN
CARBON 14 COMPOUNDS
CATS
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
DYNAMIC FUNCTION STUDIES
ELECTRICITY
GANGLIONS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MEDICINE
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRAZOLES
PYRAZOLINES
STIMULATION
SURGERY
TRACER TECHNIQUES
VERTEBRATES