Thalamic, brainstem, and cerebellar glucose metabolism in the hemiplegic monkey
Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a contralateral hemiplegia that resolves partially with time. During the phase of dense hemiplegia, local cerebral metabolic rate for glucose (1CMRG1c) is decreased significantly in most of the thalamic nuclei ipsilateral to the ablation, and there are slight contralateral decreases. The lCMRGlc is reduced bilaterally in most of the brainstem nuclei and bilaterally in the deep cerebellar nuclei, but only in the contralateral cerebellar cortex. During the phase of partial motor recovery, lCMRGlc is incompletely restored in many of the thalamic nuclei ipsilateral to the ablation and completely restored in the contralateral nuclei. In the brainstem and deep cerebellar nuclei, poor to moderate recovery occurs bilaterally. Moderate recovery occurs in the contralateral cerebellar cortex. The findings demonstrate that a unilateral cerebral cortical lesion strongly affects lCMRGlc in the thalamus ipsilaterally and in the cerebellar cortex contralaterally, but in the brainstem bilaterally. Partial recovery of lCMRGlc accompanies the progressive motor recovery. The structures affected include those with direct, and also those with indirect, connections to the areas ablated.
- Research Organization:
- Univ. of Michigan Medical School, Ann Arbor (USA)
- OSTI ID:
- 6540410
- Journal Information:
- Ann. Neurol.; (United States), Journal Name: Ann. Neurol.; (United States) Vol. 24:6; ISSN ANNED
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
AUTORADIOGRAPHY
BODY
BRAIN
CARBOHYDRATES
CELL CONSTITUENTS
CELL NUCLEI
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
GLUCOSE
HEXOSES
MAMMALS
METABOLISM
MONKEYS
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PRIMATES
SACCHARIDES
THALAMUS
VERTEBRATES