Differential intestinal absorption of two fatty acid isomers: Elaidic and oleic acids

Journal Article · Tue Dec 01 04:00:00 EST 1987 · American Journal of Physiology; (USA)

OSTI ID:6993147

Bernard, A; Echinard, B; Carlier, H ^[1]

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1. Campus Universitaire Montmuzard, Dijon (France)

The absorption of {sup 14}C-labeled oleic acid and {sup 14}C-labeled elaidic acid was studied in bile- and pancreatic juice-diverted adult rats. In some cases these acids were compared with {sup 14}C-labeled palmitic acid absorption. Sodium taurocholate-emulsified test infusates containing an equimolar mixture of monopalmitin and two fatty acids (oleic and elaidic or palmitic), one of which was {sup 14}C labeled, were infused through a duodenal canula. The chyle was collected from the mesenteric lymphatic vessel by plastic tubing. Among the three fatty acids studied, oleic acid exhibited the highest lymphatic recovery rate. Elaidic and palmitic acids appeared more slowly and in lesser amounts. Simultaneously, the highest amount of chylomicrons was observed when the lipid emulsion contained oleic acid alone; the lowest was observed when elaidic acid was the only unsaturated fatty acid. Experimental data have also shown that compared with elaidic acid, oleic acid is preferentially incorporated into the lymph triglycerides. The authors conclude from the data presented that the enterocytic enzymes involved in the absorption of lipids show a high degree of specificity related to the fatty acid isomery, since the absorption of elaidic acid differs markedly from its isomer oleic acid.

• OSTI ID: 6993147
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:6; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ADULTS
AGE GROUPS
ANIMALS
BILE
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
ELECTRON MICROSCOPY
HEXADECANOIC ACID
INTESTINAL ABSORPTION
KINETICS
LABELLED COMPOUNDS
LIPIDS
MAMMALS
MATERIALS
MEMBRANE TRANSPORT
MICROSCOPY
MONOCARBOXYLIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
RATS
RODENTS
UPTAKE
VERTEBRATES