Accelerated heavy ions and the lens. IV. Biomicroscopic and cytopathological analyses of the lenses of mice irradiated with 600 MeV/amu sup 56 Fe ions

Journal Article · Wed Nov 01 04:00:00 EST 1989 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577714· OSTI ID:6992341

Worgul, B V; Medvedovsky, C; Powers-Risius, P; Alpen, E ^[1]

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1. Columbia Univ., New York, NY (USA)

The lenses of mice exposed to 600 MeV/amu iron ions were evaluated by slit-lamp biomicroscopy and cytopathological analyses. The doses ranged from 0.05 to 1.6 Gy, and the lenses were assessed at several intervals postirradiation. Cataract, the development of which is dependent on both time and dose, is significantly more advanced in all of the exposed mice when compared to the unirradiated controls. The great difference between the severity of the cataracts caused by 0.05 Gy (the lowest dose used) and those that developed spontaneously in the control animals is an indication that 0.05 Gy may far exceed the threshold dose for the production of cataracts by accelerated iron ions. Cytopathologically, a similar dose dependence was observed for a number of end points including micronucleation, interphase death, and meridional row disorganization. In addition the exposure to the 56Fe ions produced a long-term effect on the mitotic population and a pronounced focal loss of epithelial cytoarchitecture. The microscopic changes support the view that the mechanism of heavy-ion-induced cataractogenesis is the same as that for cataracts caused by low-LET radiation.

• OSTI ID: 6992341
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 120:2; ISSN 0033-7587; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCELERATORS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CATARACTS
CRYSTALLINE LENS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ENERGY TRANSFER
EPITHELIUM
EVEN-EVEN NUCLEI
EXTERNAL IRRADIATION
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
IRON 56
IRON ISOTOPES
IRRADIATION
ISOTOPES
LET
LINEAR ACCELERATORS
MAMMALS
MICE
NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOINDUCTION
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
STABLE ISOTOPES
TIME DEPENDENCE
TISSUES
VERTEBRATES
WHOLE-BODY IRRADIATION