Relative cataractogenic effects of X rays, fission-spectrum neutrons, and 56Fe particles: A comparison with mitotic effects

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3578114· OSTI ID:6056080

Riley, E F; Lindgren, A L; Andersen, A L; Miller, R C; Ainsworth, E J ^[1]

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1. Univ. of Iowa, Iowa City (USA)

The eyes of Sprague-Dawley rats were irradiated with doses of 2.5-10 Gy 250-kVp X rays, 1.25-2.25 Gy fission-spectrum neutrons (approximately 0.85 MeV), or 0.1-2.0 Gy 600-MeV/A 56Fe particles. Lens opacifications were evaluated for 51-61 weeks following X and neutron irradiations and for 87 weeks following X and 56Fe-particle irradiations. Average stage of opacification was determined relative to time after irradiation, and the time required for 50% of the irradiated lenses to achieve various stages (T50) was determined as a function of radiation dose. Data from two experiments were combined in dose-effect curves as T50 experimental values taken as percentages of the respective T50 control values (T50-% control). Simple exponential curves best describe dose responsiveness for both high-LET radiations. For X rays, a shallow dose-effect relationship (shoulder) up to 4.5 Gy was followed at higher doses by a steeper exponential dose-effect relationship. As a consequence, RBE values for the high-LET radiations are dose dependent. Dose-effect curves for cataracts were compared to those for mitotic abnormalities observed when quiescent lens epithelial cells were stimulated mechanically to proliferate at various intervals after irradiation. Neutrons were about 1.6-1.8 times more effective than 56Fe particles for inducing both cataracts and mitotic abnormalities. For stage 1 and 2 cataracts, the X-ray Dq was 10-fold greater and the D0 was similar to those for mitotic abnormalities initially expressed after irradiation.

• OSTI ID: 6056080
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 125:3; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CATARACTS
CELL DIVISION
CELL PROLIFERATION
CRYSTALLINE LENS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ENERGY TRANSFER
EVEN-EVEN NUCLEI
EYES
FACE
FERMIONS
FISSION NEUTRONS
HADRONS
HEAD
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRON 56
IRON ISOTOPES
ISOTOPES
LET
MAMMALS
MITOSIS
NEUTRONS
NUCLEI
NUCLEONS
ORGANS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RATS
RBE
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
STABLE ISOTOPES
VERTEBRATES
X RADIATION