Comparison of recovery from potential mitotic abnormality in mitotically quiescent lens cells after X, neutron, and sup 56 Fe irradiations

Journal Article · Tue Aug 01 04:00:00 EDT 1989 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577616· OSTI ID:5472489

Riley, E F; Lindgren, A L; Miller, R C; Austin, B T; Ainsworth, E J ^[1]

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1. Univ. of Iowa, Iowa City (USA)

After exposure to various doses of 250 kVp X radiation, 0.85 Me V fission spectrum neutrons, or 600 MeV/A iron (Fe) particles, mitotically quiescent rat lens cells showed no visible evidence of radiation injury. However, following the mitogenic stimulus of wounding, mitotic abnormalities became evident when responding cells entered mitosis. Latent damage and recovery therefrom were monitored at 3, 7, 14, and 28 days after irradiation. Following doses of 1 to 10 Gy of X radiation, the recovery rate, indicated by a decrease in abnormalities with time, was proportional to dose, and the dose-effect slope decreased exponentially with time. Virtually no recovery occurred during the 28 days after 1.25 to 2.25 Gy of fission neutron radiation. After doses of 0.5 to 3.0 Gy of Fe particles, an increased expression of mitotic damage or recovery than recovery occurred. As a consequence of the differing patterns in time for expression of damage or recovery following X rays and the high-LET radiations, the relative biological effectiveness (RBE) increased from 3.6 to 16 for neutrons and from 2 to 10 for Fe particles over the 28-day observation period.

• OSTI ID: 5472489
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 119:2; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BODY
BODY AREAS
CELL DIVISION
COMPARATIVE EVALUATIONS
CRYSTALLINE LENS
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
EYES
FACE
FERMIONS
FISSION NEUTRONS
HADRONS
HEAD
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IRON 56
IRON ISOTOPES
ISOTOPES
MAMMALS
MITOSIS
NEUTRONS
NUCLEI
NUCLEONS
ORGANS
RADIATION EFFECTS
RADIATIONS
RATS
RBE
RECOVERY
RODENTS
SENSE ORGANS
STABLE ISOTOPES
VERTEBRATES
X RADIATION