Oleic acid-induced lung injury in rabbits: effect of fibrinogen depletion with Arvin

Journal Article · Tue Mar 01 04:00:00 EST 1988 · J. Appl. Physiol.; (United States)

OSTI ID:6991665

Allard, M F; Doerschuk, C M; Brumwell, M L; Belzberg, A; Hogg, J C

The role of fibrinogen in the evolution of the increased permeability after oleic acid-induced lung injury was studied in New Zealand White rabbits. Animals depleted of fibrinogen by treatment with Malayan pit viper venom were compared with untreated rabbits immediately and at 1 and 24 h after injury. The increased permeability to albumin and elevated extravascular lung water (EVLW) associated with lung injury returned to control values by 24 h in untreated animals. Fibrinogen-depleted animals had a higher mortality (10/25 vs. 2/17, P less than 0.02) and showed a greater immediate increase in permeability to albumin that returned to control values at 1 and 24 h after injury, as well as trends toward elevated blood-free dry lung weight and larger increases in EVLW that persisted for 24 h. These findings indicate that fibrinogen-related proteins play an important role in controlling the microvascular injury that is produced by oleic acid. However, when these proteins are depleted, other mechanisms partially control the leak at later stages of the repair process.

• Research Organization: Univ. of British Columbia, Vancouver (Canada)
• OSTI ID: 6991665
• Journal Information: J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 64:3; ISSN JAPYA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ANIMALS
BIOLOGICAL FUNCTIONS
BLOOD COAGULATION FACTORS
BODY
CARBOXYLIC ACIDS
COAGULANTS
DRUGS
EXTRACELLULAR SPACE
FIBRINOGEN
FUNCTIONS
GLOBULINS
HEMATOLOGIC AGENTS
HEMOSTATICS
INJURIES
ISOTOPE APPLICATIONS
ISOTOPE DILUTION
ISOTOPES
LUNGS
MAMMALS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PROTEINS
RABBITS
RADIOISOTOPES
RESPIRATORY SYSTEM
SPACE
TOXICITY
TRACER TECHNIQUES
VERTEBRATES