Effect of lung injuries on (/sup 14/C)urea permeability-surface area product in dogs

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States)

OSTI ID:5695840

Zelter, M; Lipavsky, A; Hoeffel, J M; Murray, J F

To determine whether (/sup 14/C)urea permeability-surface area product (PS) is a reliable indicator of changes in permeability in various injuries and its relationship to indicator-dilution and gravimetric lung water contents, we studied six groups of anesthetized, paralyzed, and mechanically ventilated dogs (5 animals each). The groups consisted of control dogs, those injured by intravenous alloxan, oleic acid, or glass beads, and those exposed to acute hypoxia or increased left atrial pressure from volume loading (Pla). Interanimal variation of PS was large (3.0-15.0 ml/s), but successive hourly values in individual animals were stable for 2 h in experimental groups and for 4 h in controls. The PS increased after alloxan, elevated Pla, and 2 h of hypoxia; PS decreased after oleic acid and micremboli. The gravimetric lung water increased after alloxan, oleic acid, and microemboli, and indicator-dilution lung water increased only after alloxan. We conclude (1) that intersubject variability requires normalization to enable detection of significant deviation from base line, and (2) that decreased PS after oleic acid and microvascular injury occurred because vascular obstruction, which decreased surface area, masked probable coexisting increases in capillary permeability.

• Research Organization: San Francisco General Hospital Medical Center, CA
• OSTI ID: 5695840
• Journal Information: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States), Journal Name: J. Appl. Physiol.: Respir., Environ. Exercise Physiol.; (United States) Vol. 56:6; ISSN JARPD
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALLOXAN
AMIDES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL INDICATORS
BLOOD FLOW
BLOOD VESSELS
BODY
CAPILLARIES
CARBON 14 COMPOUNDS
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
DOGS
GLASS
HETEROCYCLIC COMPOUNDS
INJURIES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LUNGS
MAMMALS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PERMEABILITY
PYRIMIDINES
RESPIRATORY SYSTEM
SURFACE AREA
SURFACE PROPERTIES
TRACER TECHNIQUES
UREA
VERTEBRATES