Regional changes in extravascular lung water detected by positron emission tomography
Journal Article
·
· J. Appl. Physiol.; (United States)
OSTI ID:5622877
Regional measurements of extravascular lung water (rEVLW) were made with positron emission tomography (PET) and 15O-labeled radionuclides. The label used to measure the total lung water (TLW) content fully equilibrated with TLW prior to scanning in both dogs with normal and low cardiac outputs, and nearly so in areas of lung made edematous by oleic acid injury (the TLW values used were 97% of maximum values). Regional EVLW measurements made by PET (EVLW-PET) and gravimetric techniques in both normal and edematous lung were closely correlated (r = 0.93), and EVLW-PET increased from an average of 0.20 to 0.37 mlH/sub 2/O/ml lung (P less than 0.05) after regional lung injury. PET measurements of regional blood volume always decreased (from an average of 0.12 to 0.09 ml blood/ml lung (P less than 0.05)) after cardiac output was lowered by hemorrhage in a separate set of animals. Total EVLW (by thermodye indicator dilution) did not change. Likewise, regional EVLW remained constant in areas below the left atrium but decreased in areas above the left atrium. We conclude that PET measurements are accurate, noninvasive, and reproducible and that regional changes may be detected even when measurements of total EVLW by other methods may fail to change significantly.
- Research Organization:
- Washington Univ. Medical School, St. Louis, MO
- OSTI ID:
- 5622877
- Journal Information:
- J. Appl. Physiol.; (United States), Journal Name: J. Appl. Physiol.; (United States) Vol. 4; ISSN JAPYA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
DYNAMIC FUNCTION STUDIES
EDEMA
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SYMPTOMS
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DOGS
DYNAMIC FUNCTION STUDIES
EDEMA
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
ISOTOPE APPLICATIONS
ISOTOPES
LUNGS
MAMMALS
MATERIALS
MONOCARBOXYLIC ACIDS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SYMPTOMS
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES