The toxicopathology of Prudhoe Bay crude oil in chicken embryos

Journal Article · Sun Dec 31 23:00:00 EST 1989 · Fundamental and Applied Toxicology; (USA)

DOI:https://doi.org/10.1016/0272-0590(90)90228-C· OSTI ID:6989073

Couillard, C M; Leighton, F A ^[1]

---

1. Univ. of Saskatchewan, Saskatoon (Canada)

Microliter amounts of Prudhoe Bay crude oil were applied to the shell of fertile leghorn chicken eggs on Day 9 of incubation. Gross and microscopic pathological changes were examined in embryos surviving 4 days after exposure. Gross lesions seen consistently were extensive edema, superficial zones of pale hepatic tissue, distension of the heart, and enlargement of the spleen. Histologically, the pale liver tissue corresponded to areas of hepatocyte necrosis. Additional histological lesions were cellular casts and mineralization in the renal tubules, distension of the glomerular capillaries, and accumulation of hematopoietic tissue in the liver and spleen. Dose-related increases in the number of mitotic figures in hepatocytes and in weights of liver, spleen, and heart were observed.

• OSTI ID: 6989073
• Journal Information: Fundamental and Applied Toxicology; (USA), Journal Name: Fundamental and Applied Toxicology; (USA) Vol. 14:1; ISSN FAATD; ISSN 0272-0590
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020600* -- Petroleum-- Health & Safety
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIRDS
BODY
CARDIOVASCULAR SYSTEM
CHICKENS
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
EGGS
EMBRYOS
ENERGY SOURCES
FOSSIL FUELS
FOWL
FUELS
GLANDS
HEART
KIDNEYS
LIVER
MORPHOLOGICAL CHANGES
NECROSIS
ORGANS
PATHOLOGICAL CHANGES
PETROLEUM
POLLUTION
TERATOGENESIS
VERTEBRATES
WATER POLLUTION
WEIGHT