Comparison of short-lived high-LET alpha-emitting radionuclides lead-212 and bismuth-212 to low-LET X-rays on ovarian carcinoma

Journal Article · Fri Dec 01 04:00:00 EST 1989 · Gynecologic Oncology; (USA)

DOI:https://doi.org/10.1016/0090-8258(89)90067-X· OSTI ID:6983641

Rotmensch, J; Atcher, R W; Hines, J; Toohill, M; Herbst, A L ^[1]

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1. Argonne National Lab., IL (USA)

We are investigating the potential use of short-lived alpha-emitting radionuclides for the treatment of ovarian carcinoma. These radionuclides transfer dense high ionizing linear energy (high LET) over a short path length without dependence upon cellular oxygen. The alpha-emitting radionuclides chosen were lead-212 and bismuth-212 which are readily available. The radiosensitivities of two ovarian carcinoma cell lines (OVC-1 and OVC-2) was greater with {sup 212}Pb and {sup 212}Bi than with X-ray therapy. D0, inversely related to the radiosensitivity, was 155 and 240 rads for OVC-1 and OVC-2, respectively. With {sup 212}Pb or {sup 212}Bi, the slope of the survival curves was steeper. The D0 was 75 and 70 rads after {sup 212}Pb and 85 and 95 rads after 212Bi treatment for OVC-1 and OVC-2, respectively. The relative biological effectiveness with alpha irradiation was two to four times greater than with X rays. Unlike low-LET irradiation (i.e., X rays and gamma emitters) the cells had no ability to accumulate or repair sublethal damage. From these experiments it is concluded that a greater therapeutic advantage may be gained with alpha-emitting radionuclides than X rays. Further development of these nuclides may provide for a new form of therapy.

• OSTI ID: 6983641
• Journal Information: Gynecologic Oncology; (USA), Journal Name: Gynecologic Oncology; (USA) Vol. 35:3; ISSN GYNOA; ISSN 0090-8258
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY RADIOISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH 212
BISMUTH ISOTOPES
BODY
CARCINOMAS
COMPARATIVE EVALUATIONS
DISEASES
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
EVEN-EVEN NUCLEI
FEMALE GENITALS
GONADS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IONIZING RADIATIONS
ISOTOPES
LEAD 212
LEAD ISOTOPES
LET
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
OVARIES
PRIMATES
RADIATIONS
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY
RADIOTHERAPY
SURVIVAL TIME
THERAPY
TUMOR CELLS
VERTEBRATES
X RADIATION