/sup 212/Bismuth linked to an antipancreatic carcinoma antibody: model for alpha-particle-emitter radioimmunotherapy
Journal Article
·
· JNCI, J. Natl. Cancer Inst.; (United States)
For comparison of cytotoxicity from alpha-particle irradiation with that from conventional x-irradiation, /sup 212/Bi, an alpha-emitting radionuclide, was attached to a monoclonal antibody that recognizes a cell surface antigen on human pancreatic carcinoma cells. For a given level of survival, the /sup 212/Bi-antibody complex was found to be approximately 20 times more efficient in cell killing than x-irradiation and 5 times more cytotoxic when compared with the cytotoxicity of an antigen-negative cell line or an isotype-matched control antibody. High linear energy transfer radioimmunotherapy using alpha emitters linked to monoclonal antibodies may be useful in vivo and in vitro for selectively killing target cell populations, especially those resistant to other forms of treatment.
- Research Organization:
- National Cancer Institute, Bethesda, MD (USA)
- OSTI ID:
- 7025669
- Journal Information:
- JNCI, J. Natl. Cancer Inst.; (United States), Journal Name: JNCI, J. Natl. Cancer Inst.; (United States) Vol. 80:6; ISSN JJIND
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY RADIOISOTOPES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH 212
BISMUTH ISOTOPES
BODY
CARCINOMAS
CELL KILLING
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
ENERGY TRANSFER
GLANDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IONIZING RADIATIONS
ISOTOPES
MEDICINE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PANCREAS
RADIATIONS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURVIVAL CURVES
THERAPEUTIC USES
THERAPY
USES
X RADIATION
62 RADIOLOGY AND NUCLEAR MEDICINE
ALPHA DECAY RADIOISOTOPES
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BISMUTH 212
BISMUTH ISOTOPES
BODY
CARCINOMAS
CELL KILLING
COMPARATIVE EVALUATIONS
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
ENERGY TRANSFER
GLANDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IONIZING RADIATIONS
ISOTOPES
MEDICINE
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PANCREAS
RADIATIONS
RADIOIMMUNOLOGY
RADIOIMMUNOTHERAPY
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SURVIVAL CURVES
THERAPEUTIC USES
THERAPY
USES
X RADIATION