Cadmium inhalation and male reproductive toxicity
- Battelle Pacific Northwest Laboratories, Richland, WA (USA)
Cadmium is a highly toxic element that is cumulative and has a long biological half-life in mammals. The severe toxicity of cadmium in man has been known for more than 100 years. Despite the knowledge that cadmium is toxic, only 20 human cases of poisoning via ingestion were recorded prior to 1941, whereas in the ensuing five-year period more than 680 cases of cadmium poisonings from accidental oral ingestion of this metal were documented. Some of the recorded effects of exposure to cadmium in laboratory animals include renal tubular damage, placental and testicular necrosis, structural and functional liver damage, osteomalacia, testicular tumors, teratogenic malformations, anemia, hypertension, pulmonary edema, chronic pulmonary emphysema, and induced deficiencies of iron, copper, and zinc. Some of these effects have also been observed in human after accidental exposures to cadmium oxide fumes and are characteristic of the syndrome described in Japan as Itai Itai disease in which ingestion of cadmium is the inciting chemical.134 references.
- OSTI ID:
- 6983237
- Journal Information:
- Reviews of Environmental Contamination and Toxicology; (USA), Journal Name: Reviews of Environmental Contamination and Toxicology; (USA) Vol. 114; ISSN 0179-5953; ISSN RCTOE
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
CADMIUM
DIGESTIVE SYSTEM
DOCUMENT TYPES
ELEMENTS
ENVIRONMENTAL EXPOSURE
GAMETES
GERM CELLS
GLANDS
GONADS
INHALATION
INTAKE
KIDNEYS
LIVER
MALE GENITALS
MAMMALS
MAN
METALS
ORGANS
PRIMATES
REVIEWS
SENSITIVITY
SPERMATOZOA
TESTES
TOXICITY
VERTEBRATES