Strain- and organ-dependent differences in induction of aryl hydrocarbon hydroxylase activity by 3-methylcholanthrene

Journal Article · Tue Aug 01 04:00:00 EDT 1989 · Bulletin of Environmental Contamination and Toxicology; (USA)

DOI:https://doi.org/10.1007/BF01701746· OSTI ID:6983114

Kiyohara, Chikako; Mohri, Noriko; Nagayama, Junya; Hirohata, Tomio ^[1]

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1. Kyushu Univ., Fukuoka (Japan)

Several polyaromatic hydrocarbons are suspected to be carcinogenic and may be a major cause of the human lung cancer. In the murine tissues, liver, lung, kidney, small intestine, lymphocytes etc., the first step of the metabolism of polyaromatic hydrocarbons involves the enzyme aryl hydrocarbon hydroxylase (AHH), which is known as a component of the microsomal mixed function oxidase system dependent on NADPH and cytochrome P-450 (P-450). Hepatic and extrahepatic AHH is induced by polyaromatic hydrocarbons such as 3-methylcholanthrene (MC) and the inducibility is under the control of the aromatic hydrocarbon (Ah) locus; certain inbred strains of mice are susceptible of AHH induction by MC treatment (Ah responsive strains), while other inbred strains are not (Ah non-responsive strains). The objective of this study is to understand more fully strain- and organ-dependent differences in inducibility of AHH by MC with the genetically established mouse strains as materials. Also the AHH levels of blood lymphocytes and splenic lymphocytes are compared with those of several freshly excised organs of the strains of mice.

• OSTI ID: 6983114
• Journal Information: Bulletin of Environmental Contamination and Toxicology; (USA), Journal Name: Bulletin of Environmental Contamination and Toxicology; (USA) Vol. 43:2; ISSN 0007-4861; ISSN BECTA
• Country of Publication: United States
• Language: English

Related Subjects

3-METHYLCHOLANTHRENE
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CONSTITUENTS
CONDENSED AROMATICS
CONNECTIVE TISSUE CELLS
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
GENE REGULATION
HYDROCARBONS
HYDROXYLASES
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
METABOLISM
MICE
MICROSOMES
ORGANIC COMPOUNDS
ORGANOIDS
OXIDOREDUCTASES
POLYCYCLIC AROMATIC HYDROCARBONS
RIBOSOMES
RODENTS
SOMATIC CELLS
VERTEBRATES