Induction of hepatic aryl hydrocarbon hydroxylase in C57BL mice by ionizing radiation
Journal Article
·
· Cancer Res.; (United States)
OSTI ID:5760630
Inbred strains of C57BL mice were exposed to either 100, 500, or 1000 rads of whole-body irradiation. Another group of mice were given injections of 3-methylcholanthrene only, and a control group had no treatment. Forty-eight h after treatment, the animals were killed and hepatic aryl hydrocarbon hydroxylase (AHH) activity was measured by spectrophotofluorometer. A comparison of hepatic AHH activity in treated and nontreated groups of mice showed that each treated group had a significantly increased AHH induction compared with the control group. Although radiation appeared to have a dose-related effect on AHH induction, the increase with dose level was not statistically significant.
- Research Organization:
- Baylor Coll. of Medicine, Houston, TX
- OSTI ID:
- 5760630
- Journal Information:
- Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 37:10; ISSN CNREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CATALYSIS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ENZYMES
EXTERNAL IRRADIATION
HYDROXYLASE
IRRADIATION
MAMMALS
METABOLISM
MICE
OXIDOREDUCTASES
RADIATION DOSES
RADIATION EFFECTS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION
560114* -- Radiation Effects on Biochemicals-- In Animals-- (-1987)
560152 -- Radiation Effects on Animals-- Animals
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CATALYSIS
COMPARATIVE EVALUATIONS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ENZYMES
EXTERNAL IRRADIATION
HYDROXYLASE
IRRADIATION
MAMMALS
METABOLISM
MICE
OXIDOREDUCTASES
RADIATION DOSES
RADIATION EFFECTS
RODENTS
VERTEBRATES
WHOLE-BODY IRRADIATION