Radioimmunoassay of leukocyte (alpha) interferon and its application to some clinical conditions
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:6983010
A radioimmunoassay for human leukocyte interferon alpha (alpha IFN) has been developed, using tracer produced by recombinant DNA (IFLrA) and polyclonal rabbit antiserum against partially purified leukocyte IFN (PP alpha IFN). Sensitivity was 4 units/ml using sequential saturation. Only lymphoblastoid IFN showed complete cross reactivity. Serum alpha IFN concentrations were measured in normal subjects and in patients with acute viral infection, bone and joint diseases, and malignancies. Some cases in the first two groups of patients had significantly elevated serum levels compared with controls. The pharmacokinetics of alpha IFN were studied in treated cancerous patients. Radioimmunoassay and biological assay gave similar and closely correlated results.
- Research Organization:
- Univ. of Liege, Belgium
- OSTI ID:
- 6983010
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:7; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOMAS
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DNA
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
INFECTIOUS DISEASES
INFORMATION
INTERFERON
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MATERIALS
METASTASES
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RECOMBINANT DNA
SARCOMAS
TRACER TECHNIQUES
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARCINOMAS
DATA
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DNA
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL DATA
INFECTIOUS DISEASES
INFORMATION
INTERFERON
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LEUKOCYTES
MATERIALS
METASTASES
NEOPLASMS
NUCLEI
NUCLEIC ACIDS
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATIENTS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOISOTOPES
RECOMBINANT DNA
SARCOMAS
TRACER TECHNIQUES