Determination of left ventricular mass by single-photon emission computed tomography with thallium-201

Journal Article · Tue May 01 04:00:00 EDT 1984 · Am. J. Cardiol.; (United States)

DOI:https://doi.org/10.1016/0002-9149(84)90095-X· OSTI ID:6975016

Wolfe, C L; Corbett, J R; Lewis, S E; Buja, L M; Willerson, J T

To test the hypothesis that single-photon emission computed tomography (SPECT) might permit accurate, noninvasive measurement of LV mass, SPECT measurements of LV mass to LV weight were compared in 20 mongrel dogs. Projection images of the left ventricle were acquired after intravenous injection of thallium-201 (TI-201). Transverse sections were reconstructed using filtered backprojection. Coronal sections were extracted from the reconstructed volume. The boundary of LV uptake of TI-201 in each coronal section was defined automatically using a threshold detector. Scintigraphic LV mass (total number of volume elements (voxels) showing TI-201 uptake X voxel volume X specific gravity of myocardium) was compared to actual LV weight. There was good correlation between scintigraphic LV mass and LV weight. Mean LV weight was 68 +/- 20 g (+/- standard deviation) (range 27 to 94). Mean SPECT LV mass was 66 +/- 19 g (range 28 to 100). Linear regression analysis yielded the following relation: SPECT LV mass . 0.87 X LV weight + 6.79 (r . 0.91, root-mean-square deviation from regression . 7.5). SPECT measurements were reproducible, with a coefficient of variation of 0.24%. Thus, SPECT of LV TI-201 distribution can be used to measure LV mass in canine myocardium.

• Research Organization: Department of Internal Medicine Cardiology Division, University of Texas Health Science Center
• OSTI ID: 6975016
• Journal Information: Am. J. Cardiol.; (United States), Journal Name: Am. J. Cardiol.; (United States) Vol. 53:9; ISSN AJCDA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HEART
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
VERTEBRATES